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Mouse VCAM-1

Mouse VCAM-1

Manufacturer	GENWAY
Category	Oncology Neuroscience Neuroinflammation Antibodies Cell Biology Cell Movement Cell Adhesion Primary Antibodies By Organ Renal Cancer
Type	Antibody
Specific against	Mouse
Clone	M/K-2
Amount	1mg
Item no.	20-511-242045
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-3645C4
Isotype:	IgG1. k (Rat)
Clone:	M/K-2Host Animal: Rat
Specificity:	CD106. VCAM-1
Type of Product:	Monoclonal Antibodies to Non-Human CDs
Concentration:	0. 5mg/mlPreservatives: NaN3
Buffer:	PBSApplications Notes : Studies of cell-cell interaction. . Cell adhesion assays. . Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures. . Immunoprecipitation of the VCAM-1 integrin complex. . Detection of VCAM-1 cells by immunofluorescence and immunohistochemical staining. . Does not work in paraffin sections. . Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Mouse VCAM-1. Monoclonal Antibody to Mouse Vascular Adhesion Molecule-1 (VCAM-1)
Function:	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:	Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Expressed on inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:	By cytokines (e. g. IL-1 TNF-alpha).
Domain:	Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:	Sialoglycoprotein.
Disease:	May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
Similarity:	Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mg

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Delivery expected until 6/13/2024