RAT ANTI MOUSE ABCA1:FITC

GWB-760725

IgG2a

Phosphate buffered saline pH7. 4

ABCA1 transfected HeLa cells.

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport By similarity. Subunit structureInteracts with MEGF10. Ref. 5Subcellular locationMembrane; Multi-pass membrane protein Potential. Tissue specificityWidely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.

Multifunctional polypeptide with two homologous halves each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Post-translational modificationPhosphorylation on Ser-2054 regulates phospholipid efflux By similarity. Palmitoylation by DHHC8 is essential for membrane localization By similarity. Sequence similaritiesBelongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Sequence cautionThe sequence AAG39073. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA53530. 1 differs from that shown. Reason: Erroneous initiation. 1. Suriben R. et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat. Genet. 41: 977-985 [1] \" Dapper a Dishevelled-associated antagonist of beta-catenin and JNK signaling is required for notochord formation. \" Cheyette B. N. R. Waxman J. S. Miller J. R. Takemaru K. Sheldahl L. C. Khlebtsova N. Fox E. P. Earnest T. N. Moon R. T. Dev. Cell 2:449-461(2002) [PubMed: 11970895] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] INTERACTION WITH DVL2 TISSUE SPECIFICITY. Tissue: Cerebellum. [2] \" Developmental expression of mouse Frodo. \" Hikasa H. Sokol S. Y. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-511. Strain: FVB/N. [3] \" The transcriptional landscape of the mammalian genome. \" Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. Shimokawa K. Bajic V. B. Brenner S. E. Batalov S. Forrest A. R. Zavolan M. Davis M. J. Wilming L. G. Aidinis V. Allen J. E. Ambesi-Impiombato A. Apweiler R. Aturaliya R. N. Bailey T. L. Bansal M. Baxter L. Beisel K. W. Bersano T. Bono H. Chalk A. M. Chiu K. P. Choudhary V. Christoffels A. Clutterbuck D. R. Crowe M. L. Dalla E. Dalrymple B. P. de Bono B. Della Gatta G. di Bernardo D. Down T. Engstrom P. Fagiolini M. Faulkner G. Fletcher C. F. Fukushima T. Furuno M. Futaki S. Gariboldi M. Georgii-Hemming P. Gingeras T. R. Gojobori T. Green R. E. Gustincich S. Harbers M. Hayashi Y. Hensch T. K. Hirokawa N. Hill D. Huminiecki L. Iacono M. Ikeo K. Iwama A. Ishikawa T. Jakt M. Kanapin A. Katoh M. Kawasawa Y. Kelso J. Kitamura H. Kitano H. Kollias G. Krishnan S. P. Kruger A. Kummerfeld S. K. Kurochkin I. V. Lareau L. F. Lazarevic D. Lipovich L. Liu J. Liuni S. McWilliam S. Madan Babu M. Madera M. Marchionni L. Matsuda H. Matsuzawa S. Miki H. Mignone F. Miyake S. Morris K. Mottagui-Tabar S. Mulder N. Nakano N. Nakauchi H. Ng P. Nilsson R. Nishiguchi S. Nishikawa S. Nori F. Ohara O. Okazaki Y. Orlando V. Pang K. C. Pavan W. J. Pavesi G. Pesole G. Petrovsky N. Piazza S. Reed J. Reid J. F. Ring B. Z. Ringwald M. Rost B. Ruan Y. Salzberg S. L. Sandelin A. Schneider C. Schoenbach C. Sekiguchi K. Semple C. A. Seno S. Sessa L. Sheng Y. Shibata Y. Shimada H. Shimada K. Silva D. Sinclair B. Sperling S. Stupka E. Sugiura K. Sultana R. Takenaka Y. Taki K. Tammoja K. Tan S. L. Tang S. Taylor M. S. Tegner J. Teichmann S. A. Ueda H. R. van Nimwegen E. Verardo R. Wei C. L. Yagi K. Yamanishi H. Zabarovsky E. Zhu S. Zimmer A. Hide W. Bult C. Grimmond S. M. Teasdale R. D. Liu E. T. Brusic V. Quackenbush J. Wahlestedt C. Mattick J. S. Hume D. A. Kai C. Sasaki D. Tomaru Y. Fukuda S. Kanamori-Katayama M. Suzuki M. Aoki J. Arakawa T. Iida J. Imamura K. Itoh M. Kato T. Kawaji H. Kawagashira N. Kawashima T. Kojima M. Kondo S. Konno H. Nakano K. Ninomiya N. Nishio T. Okada M. Plessy C. Shibata K. Shiraki T. Suzuki S. Tagami M. Waki K. Watahiki A. Okamura-Oho Y. Suzuki H. Kawai J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-778. Strain: C57BL/6J. Tissue: Embryo. [4] \" Cloning of a murine cDNA and its human homolog encoding transcription factor-like proteins. \" Gong S. Qian X. Fu W. Chen W. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 17:280-287(2001)Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 189-778. [5] \" Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. \" Fisher D. A. Kivimaee S. Hoshino J. Suriben R. Martin P. -M. Baxter N. Cheyette B. N. R. Dev. Dyn. 235:2620-2630(2006) [PubMed: 16881060] [Abstract]Cited for: TISSUE SPECIFICITY DEVELOPMENTAL STAGE.