RAT ANTI MOUSE ABCA1:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314676
Available
Genway ID:
GWB-760725
Specificity:
ABCA1
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:
ABCA1 transfected HeLa cells.
Specificity:
Recognises murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangiers disease a genetic disorder of lipid metabolism and familial high density lipoprotein (HDL) deficiency. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROL:FITC
Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport By similarity. Subunit structureInteracts with MEGF10. Ref. 5Subcellular locationMembrane; Multi-pass membrane protein Potential. Tissue specificityWidely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.
Induction:
Down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). Ref. 3Ref. 4
Domain:
Multifunctional polypeptide with two homologous halves each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Post-translational modificationPhosphorylation on Ser-2054 regulates phospholipid efflux By similarity. Palmitoylation by DHHC8 is essential for membrane localization By similarity. Sequence similaritiesBelongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Sequence cautionThe sequence AAG39073. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA53530. 1 differs from that shown. Reason: Erroneous initiation. 1. Suriben R. et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat. Genet. 41: 977-985 [1] \" Dapper a Dishevelled-associated antagonist of beta-catenin and JNK signaling is required for notochord formation. \" Cheyette B. N. R. Waxman J. S. Miller J. R. Takemaru K. Sheldahl L. C. Khlebtsova N. Fox E. P. Earnest T. N. Moon R. T. Dev. Cell 2:449-461(2002) [PubMed: 11970895] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] INTERACTION WITH DVL2 TISSUE SPECIFICITY. Tissue: Cerebellum. [2] \" Developmental expression of mouse Frodo. \" Hikasa H. Sokol S. Y. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-511. Strain: FVB/N. [3] \" The transcriptional landscape of the mammalian genome. \" Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. Shimokawa K. Bajic V. B. Brenner S. E. Batalov S. Forrest A. R. Zavolan M. Davis M. J. Wilming L. G. Aidinis V. Allen J. E. Ambesi-Impiombato A. Apweiler R. Aturaliya R. N. Bailey T. L. Bansal M. Baxter L. Beisel K. W. Bersano T. Bono H. Chalk A. M. Chiu K. P. Choudhary V. Christoffels A. Clutterbuck D. R. Crowe M. L. Dalla E. Dalrymple B. P. de Bono B. Della Gatta G. di Bernardo D. Down T. Engstrom P. Fagiolini M. Faulkner G. Fletcher C. F. Fukushima T. Furuno M. Futaki S. Gariboldi M. Georgii-Hemming P. Gingeras T. R. Gojobori T. Green R. E. Gustincich S. Harbers M. Hayashi Y. Hensch T. K. Hirokawa N. Hill D. Huminiecki L. Iacono M. Ikeo K. Iwama A. Ishikawa T. Jakt M. Kanapin A. Katoh M. Kawasawa Y. Kelso J. Kitamura H. Kitano H. Kollias G. Krishnan S. P. Kruger A. Kummerfeld S. K. Kurochkin I. V. Lareau L. F. Lazarevic D. Lipovich L. Liu J. Liuni S. McWilliam S. Madan Babu M. Madera M. Marchionni L. Matsuda H. Matsuzawa S. Miki H. Mignone F. Miyake S. Morris K. Mottagui-Tabar S. Mulder N. Nakano N. Nakauchi H. Ng P. Nilsson R. Nishiguchi S. Nishikawa S. Nori F. Ohara O. Okazaki Y. Orlando V. Pang K. C. Pavan W. J. Pavesi G. Pesole G. Petrovsky N. Piazza S. Reed J. Reid J. F. Ring B. Z. Ringwald M. Rost B. Ruan Y. Salzberg S. L. Sandelin A. Schneider C. Schoenbach C. Sekiguchi K. Semple C. A. Seno S. Sessa L. Sheng Y. Shibata Y. Shimada H. Shimada K. Silva D. Sinclair B. Sperling S. Stupka E. Sugiura K. Sultana R. Takenaka Y. Taki K. Tammoja K. Tan S. L. Tang S. Taylor M. S. Tegner J. Teichmann S. A. Ueda H. R. van Nimwegen E. Verardo R. Wei C. L. Yagi K. Yamanishi H. Zabarovsky E. Zhu S. Zimmer A. Hide W. Bult C. Grimmond S. M. Teasdale R. D. Liu E. T. Brusic V. Quackenbush J. Wahlestedt C. Mattick J. S. Hume D. A. Kai C. Sasaki D. Tomaru Y. Fukuda S. Kanamori-Katayama M. Suzuki M. Aoki J. Arakawa T. Iida J. Imamura K. Itoh M. Kato T. Kawaji H. Kawagashira N. Kawashima T. Kojima M. Kondo S. Konno H. Nakano K. Ninomiya N. Nishio T. Okada M. Plessy C. Shibata K. Shiraki T. Suzuki S. Tagami M. Waki K. Watahiki A. Okamura-Oho Y. Suzuki H. Kawai J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-778. Strain: C57BL/6J. Tissue: Embryo. [4] \" Cloning of a murine cDNA and its human homolog encoding transcription factor-like proteins. \" Gong S. Qian X. Fu W. Chen W. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 17:280-287(2001)Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 189-778. [5] \" Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. \" Fisher D. A. Kivimaee S. Hoshino J. Suriben R. Martin P. -M. Baxter N. Cheyette B. N. R. Dev. Dyn. 235:2620-2630(2006) [PubMed: 16881060] [Abstract]Cited for: TISSUE SPECIFICITY DEVELOPMENTAL STAGE.
Amount: 0.1 mg
Available: In stock
Listprice: €290.22
Discount: -10.0%
Price: €261.20
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