RAT ANTI MOUSE CD4:Biotin

GWB-AD99B4

IgG2a

Phosphate buffered saline pH7. 2

BALB/c mouse thymocytes

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Subunit structureAssociates with p56-LCK. Interacts with SPG21 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Molecular cloning cDNA sequence and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. \" Volinia S. Hiles I. Ormondroyd E. Nizetic D. Antonacci R. Rocchi M. Waterfield M. Genomics 24:472-477(1994) [PubMed: 7713498] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANTS VAL-43 AND ARG-332. [2] \" Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3\' -hydroxykinase. \" Stirdivant S. M. Ahern J. Conroy R. R. Barnett S. F. Ledder L. M. Oliff A. Heimbrook D. C. Bioorg. Med. Chem. 5:65-74(1997) [PubMed: 9043658] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. [4] \" Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha. \" RIKEN structural genomics initiative (RSGI)Submitted (APR-2008) to the PDB data bankCited for: STRUCTURE BY NMR OF 331-481. [5] \" Mutations of PIK3CA in anaplastic oligodendrogliomas high-grade astrocytomas and medulloblastomas. \" Broderick D. K. Di C. Parrett T. J. Samuels Y. R. Cummins J. M. McLendon R. E. Fults D. W. Velculescu V. E. Bigner D. D. Yan H. Cancer Res. 64:5048-5050(2004) [PubMed: 15289301] [Abstract]Cited for: VARIANTS CANCER LYS-542; LYS-545; PRO-546; ASN-1021; ARG-1047; LEU-1047 AND TYR-1065. [6] \" Mutation of the PIK3CA gene in ovarian and breast cancer. \" Campbell I. G. Russell S. E. Choong D. Y. H. Montgomery K. G. Ciavarella M. L. Hooi C. S. F. Cristiano B. E. Pearson R. B. Phillips W. A. Cancer Res. 64:7678-7681(2004) [PubMed: 15520168] [Abstract]Cited for: VARIANTS CANCER GLY-545; LYS-545; LYS-546; GLU-546; ARG-1047 AND LEU-1047. [7] \" High frequency of mutations of the PIK3CA gene in human cancers. \" Samuels Y. Wang Z. Bardelli A. Silliman N. Ptak J. Szabo S. Yan H. Gazdar A. Powell S. M. Riggins G. J. Willson J. K. V. Markowitz S. Kinzler K. W. Vogelstein B. Velculescu V. E. Science 304:554-554(2004) [PubMed: 15016963] [Abstract]Cited for: VARIANT CANCER ARG-1047. [8] \" PIK3CA mutations in glioblastoma multiforme. \" Hartmann C. Bartels G. Gehlhaar C. Holtkamp N. von Deimling A. Acta Neuropathol. 109:639-642(2005) [PubMed: 15924253] [Abstract]Cited for: VARIANTS CANCER GLN-88; LYS-542; ALA-545 AND ASN-1025. [9] \" Mutations of PIK3CA in gastric adenocarcinoma. \" Li V. S. W. Wong C. W. Chan T. L. Chan A. S. W. Zhao W. Chu K. -M. So S. Chen X. Yuen S. T. Leung S. Y. BMC Cancer 5:29-29(2005) [PubMed: 15784156] [Abstract]Cited for: VARIANTS CANCER LYS-542; LYS-545 AND ARG-1047. [10] \" Functional analysis of PIK3CA gene mutations in human colorectal cancer. \" Ikenoue T. Kanai F. Hikiba Y. Obata T. Tanaka Y. Imamura J. Ohta M. Jazag A. Guleng B. Tateishi K. Asaoka Y. Matsumura M. Kawabe T. Omata M. Cancer Res. 65:4562-4567(2005) [PubMed: 15930273] [Abstract]Cited for: CHARACTERIZATION OF VARIANTS CANCER HIS-38; VAL-106; ARG-420; GLN-453; LYS-542; LYS-545; ILE-1043 AND ARG-1047.