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Rat Anti-Mouse TNF-

Rat Anti-Mouse TNF-

Manufacturer	GENWAY
Category	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Hepatic Cancer
Type	Antibody
Specific against	Mouse
Clone	MP6-XT3
Applications	WB, ELISA
Amount	0.5 mg
Host	Rat
Item no.	20-787-276325
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-7E1D2E
Isotype:	Rat IgG1 kappa
Clone:	MP6-XT3
Immunogen:	E. coli-expressed recombinant mouse TNF-alpha
Characterization:	To ensure acceptable performance each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
Specificity:	Mouse Tumor Necrosis Factor- (TNF-)^1 2 This is a neutralizing antibody.
Warning:	Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Function:	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Subunit:	Homotrimer.
Subcellular Location:	Cell membrane; Single-pass type II membrane protein.
Subcellular Location:	Tumor necrosis factor soluble form: Secreted.
Ptm:	The soluble form derives from the membrane form by proteolytic processing.
Ptm:	The membrane form but not the soluble form is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
Disease:	Cachexia accompanies a variety of diseases including cancer and infection and is characterized by general ill health and malnutrition.
Disease:	Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red scaly skin lesions that are usually found on the scalp elbows and knees and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.
Disease:	Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection acute self-limited hepatitis or fulminant hepatitis requiring liver transplantation.
Similarity:	Belongs to the tumor necrosis factor family. Abrams J. S. M. -G. Roncarolo H. . Yssel U. Andersson G. J. Gleich and J. E. Silver. 1992. Immunol. Rev. 127:5. Abrams J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn A. Kruisbeek D. Margulies E. Shevach W. Strober eds. ). John Wiley and Sons New York. Unit 6. 20.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

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Delivery expected until 6/13/2024