HOXD3 (homeobox D3)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human HOXD3.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. HOXD3 (homeobox D3) belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox ge

Nucleus.

Contains 1 homeobox DNA-binding domain. Summary: This protein belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters HOXA HOXB HOXC and HOXD located on different chromosomes consisting of 9 to 11 genes arranged in tandem. This protein is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5\' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. Boudreau. N. J. . et al. . (2004) J. Biol. Chem. 279(6). 4862-4868.