Comparison

THRAP5 (thyroid hormone receptor associated protein 5)

Item no. 18-003-42176
Manufacturer GENWAY
Amount 0.1 mg
Category
Type Antibody
Applications WB, IHC
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-282548
Similar products 18-003-42176
Available
Genway ID:
GWB-282548
Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human THRAP5.
ELISA Titre:
1:312500
Note:
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. THRAP5 is part of the human thyroid hormone receptor-associated protein (TRAP)-Mediator family which acts as a coactivator for a broad range of nuclear hormone receptors as well as other classes of transcriptional activators.
Function:
Component of the Mediator complex a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subunit:
Component of the Mediator complex which is composed of MED1 MED4 MED6 MED7 MED8 MED9 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 CCNC CDK8 and CDC2L6/CDK11. The MED12 MED13 CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC CRSP DRIP PC2 SMCC and TRAP.
Subcellular Location:
Nucleus (Probable).
Similarity:
Belongs to the Mediator complex subunit 16 family.
Similarity:
Contains 5 WD repeats. Wang. Q. . et al. . (2002) J. Biol. Chem. 277 (45). 42852-42858.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.1 mg
Available: In stock
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