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PHKG2 (phosphorylase kinase. gamma 2 (testis))

PHKG2 (phosphorylase kinase. gamma 2 (testis))

Item no.	18-003-42332
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody
Applications	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AE6E22
Similar products	18-003-42332
Available
Genway ID:	GWB-AE6E22
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human PHKG2. Western Blot: Suggested dilution at 0. 5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.
ELISA Titre:	1:62500
Category:	Protein Kinases
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Mutations in PHKG2 along with PHKA2 and PHKB. all three different genes of phosphorylase kinase (Phk) subunits. can give rise to glycogen storage disease of the liver. The autosomal-recessive. liver-specific variant of Phk deficiency is caused by mutation
Function:	Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates including troponin I. This isozyme may regulate glycogeneolysis in the testis.
Catalytic Activity:	2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
Subunit:	Polymer of 16 chains four each of alpha beta gamma and delta. Alpha and beta are regulatory chains gamma is the catalytic chain and delta is calmodulin.
Disease:	Defects in PHKG2 are a cause of glycogen storage disease type 9C (GSD9C) [MIM:172471]; also known as autosomal liver glycogenosis. GSD9C is a metabolic disorder manifesting in infancy with hepatomegaly growth retardation and elevated plasma aminotransferases and lipids.
Similarity:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Similarity:	Contains 1 protein kinase domain. Burwinkel. B. . et al. . (1998) Hum. Mol. Genet. 7 (1). 149-154.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 11/27/2025

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