CACNA2D1 (calcium channel. voltage-dependent. alpha 2/delta subunit 1)

GWB-F0194E

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CACNA2D1 encodes a member of the alpha-2/delta subunit family. a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1. allpha-2/delta beta and gamma subunits in a 1:1:1:1 ratio.

Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1 (CACNA1) alpha-2 (CACNA2D) beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).

Central nervous system skeletal muscle and aorta tissues.

Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By similarity).

Belongs to the calcium channel subunit alpha-2/delta family.

Contains 1 VWFA domain. Summary: This protein is a member of the alpha-2/delta subunit family a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1 alpha-2/delta beta and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. Stotz. S. C. . et al. . (2004) J. Biol. Chem. 279 (5). 3793-3800.