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KCNK3 (potassium channel. subfamily K. member 3)

KCNK3 (potassium channel. subfamily K. member 3)

Item no.	18-003-42620
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-892ACE
Similar products	18-003-42620
Available
Genway ID:	GWB-892ACE
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human KCNK3. Western Blot: Suggested dilution at 1. 25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.
ELISA Titre:	1:1562500
Category:	Signal Protein
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots there is currently no sequence available to confirm transcript variants for this gene
Function:	pH-dependent voltage-insensitive background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high current is inward.
Subcellular Location:	Membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:	Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain lung prostate heart kidney uterus small intestine and colon.
Miscellaneous:	Inhibited by external acidification. Activated by halothane and isoflurane.
Similarity:	Belongs to the two pore domain potassium channel (TC 1. A. 1. 8) family [view classification]. Summary: This protein is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots there is currently no sequence available to confirm transcript variants for this gene. Rusznak. Z. . et al. . (2004) Cell. Mol. Life Sci. 61 (12). 1532-1542.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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