CACNB4 (calcium channel. voltage-dependent. beta 4 subunit)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CACNB4.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CACNB4 is a member of the beta subunit family. a protein in the voltage-dependent calcium channel complex. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition. increasing peak calcium current. controlling the alphSummary: This protein is a member of the beta subunit family a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1 alpha-2/delta beta and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition increasing peak calcium current controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene encoding different isoforms have been characterized. Suzuki. Y. . et al. . (2004) Genome Res. 14 (9). 1711-1718.