IgA

Item no.	18-272-198361
Manufacturer	GENWAY
Amount	0.05 ml
Category	Oncology Antibodies Immunohistochemistry Secondary Antibodies By Organ Lymphatic System Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-59B97E
Similar products	18-272-198361
Available
Genway ID:	GWB-59B97E
Immunogen:	Purified human IgA
Antigen Species:	Human
Specificity:	IgA is the most common immunoglobulin in the human body although the great majority is secreted from mucosal tissues rather than being found in the serum. Immunohistochemical detection of immunoglobulins is useful in the assessment of lymphoid proliferations as reactive or malignant.
Positive Control:	Human Tonsil
Target:	IgA
Concentration:	antiserum
Purification Note:	From polyclonal serum Storage
Buffer:	Phosphate buffered saline containing 0. 09% sodium azide and 1% BSA
Application Note:	IHC-Fr: Use at a dilution of 1:10 - 1:40. IHC-P: Use at a dilution of 1:10 - 1:40. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Function:	Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Subunit:	Monomeric or polymeric.
Ptm:	3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
Disease:	A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1; 14)(q21; q32) that forms a FCRL4-IGHA1 fusion protein.
Similarity:	Contains 3 Ig-like (immunoglobulin-like) domains.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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