C-X-C chemokine receptor type 4

N-terminal extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (7 ug/ml) (Optimal dilution to be determined by the researcher)

Interacts with HIV-1 surface protein gp120.

Expressed in numerous tissues such as peripheral blood leukocytes spleen thymus spinal cord heart placenta lung liver skeletal muscle kidney pancreas cerebellum cerebral cortex and medulla (in microglia as well as in astrocytes) brain microvascular coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Sulfated.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein is a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts hypogammaglobulinemia infections and myelokathexis) syndrome. Alternate transcriptional splice variants encoding different isoforms have been characterized. [1] Feng Y. Broder C. C. Kennedy P. E. Berger E. A. HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven Transmembrane G Protein-Coupled Recetor. [2] Nakata Y. Tomkowicz B. Gewirtz A. M. and Ptasznik A. et al. Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells[3] Oda Y. Yamamoto H. Tamiya S. Matsuda S. Tanaka K. Yokoyama R. Iwamoto Y. and Tsuneyoshi M. CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients all of whom developed lung metastasis[4] Holland J. D. Kochetkova M. Akekawatchai C. Dottore M. Lopez A. and McColl S. R. Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells[5] Wu S. Gessner R. Taube T. Korte A. von Stackelberg A. Kirchner R. Henze G. and Seeger K. Chemokine IL-8 and chemokine receptor CXCR3 and CXCR4 gene expression in childhood acute lymphoblastic leukemia at first relapse[6] Chang K. P. Hao S. P. Lin S. Y. Ueng S. H. Pai P. C. Tseng C. K. Hsueh C. Hsieh M. S. Yu J. S. and Tsang N. M. The 30-bp deletion of Epstein-Barr virus latent membrane protein-1 gene has no effect in nasopharyngeal carcinoma[7] Herzog H. Hort Y. J. Shine J. Selbie L. A. Molecular cloning characterization and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. [8] Jazin E. E. Yoo H. Blomqvist A. G. Yee F. Weng G. Walker M. W. Salon J. Larhammar D. Wahlestedt C. R. A proposed bovine neuropeptide Y (NPY) receptor cDNA clone or its human homologue confers neither NPY binding sites nor NPY responsiveness on transfected cells. [9] Federsppiel B. Melhado I. G. Duncan A. M. Delaney A. D. Schappert K. T. Clark-Lewis I. Jirik F. R. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen.