Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Mouse

Blue Ice

16, 9

Lyophilized from 0.2um filtered PBS, pH 7.4

Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.

Biological Activity:
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.

Sequence:
VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD

Molecular Weight:
16.9kD

PubMed ID:
11093146; 10744718; 11466363; 16141072; 17908936; 18284608; 21860022; 21965679; 12974628

Gene Name:
IL36RN, Fil1d, Il1f5, Il1h3, Il1hy1

Swiss Prot:
Q9QYY1

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.