C-C chemokine receptor type 6

GWB-CB0630

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Spleen lymph nodes appendix and fetal liver. Expressed in lymphocytes T-cells and B-cells but not in natural killer cells monocytes or granulocytes.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein is a member of the beta chemokine receptor family which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [1] Ghadjar P. Coupland S. E. Na I. K. Noutsias M. Letsch A. Stroux A. Bauer S. Buhr H. J. Thiel E. Scheibenbogen C. and et al. Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer[2] Rubie C. Oliveira V. Kempf K. Wagner M. Tilton B. Rau B. Kruse B. Konig J. and Schilling M. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis[3] Woltman A. M. de Fijter J. W. van der Kooij S. W. Jie K. E. Massacrier C. Caux C. Daha M. R. and van Kooten C. MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection[4] Yang C. C. Ogawa H. Dwinell M. B. McCole D. F. Eckmann L. and Kagnoff M. F. Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells[5] Kimsey T. F. Campbell A. S. Albo D. Wilson M. and Wang T. N. et al. Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor CCR6 promotes pancreatic cancer cell invasion[6] Baba M. Imai T. Nishimura M. Kakizaki M. Takagi S. Hieshima K. Nomiyama H. Yoshie O. Identification of CCR6 the specific receptor for a novel lymphocyte-directed CC chemokine LARC. [7] Lautens L. L. Modi W. Bonner T. I. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. [8] Zaballos A. Varona R. Gutierrez J. Lind P. Marquez G. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. [9] McCoy R. Perlmutter D. H. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. [10] Liao F. Lee H. -H. Farber J. M. Cloning of STRL22 a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27.