Putative G-protein coupled receptor 44

GWB-3258A7

Orphan receptor.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: G protein-coupled receptors (GPCRs) such as GPR44 are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins ultimately resulting in a physiologic response. [supplied by OMIM]. [1] Sandig H. Andrew D. Barnes A. A. Sabroe I. and Pease J. et al. 9alpha 11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor CRTH2[2] Hata A. N. Lybrand T. P. and Breyer R. M. et al. Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2[3] Gazi L. Gyles S. Rose J. Lees S. Allan C. Xue L. Jassal R. Speight G. Gamble V. and Pettipher R. Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes[4] Venet F. Lepape A. Debard A. L. Bienvenu J. Bohe J. and Monneret G. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock[5] Huang J. L. Gao P. S. Mathias R. A. Yao T. C. Chen L. C. Kuo M. L. Hsu S. C. Plunkett B. Togias A. Barnes K. C. Stellato C. et al. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability[6] Marchese A. Sawzdargo M. Nguyen T. Cheng R. Heng H. H. Nowak T. Im D. -S. Lynch K. R. George S. R. O\' Dowd B. F. et al. Discovery of three novel orphan G-protein-coupled receptors. [7] Nagata K. Tanaka K. Ogawa K. Kemmotsu K. Imai T. Yoshie O. Abe H. Tada K. Nakamura M. Sugamura K. et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. [8] Methner A. Schroeder S. Tissue expression and chromosomal organization of a novel G protein-coupled receptor. [9] King M. M. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [10] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.