Frizzled-9

GWB-1FA1DE

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway which leads to the activation of disheveled proteins inhibition of GSK-3 kinase nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Expressed predominantly in adult and fetal brain testis eye skeletal muscle and kidney. Moderately expressed in pancreas thyroid adrenal cortex small intestine and stomach. Detected in fetal liver and kidney.

The FZ domain is involved in binding with Wnt ligands (By similarity).

Contains 1 FZ (frizzled) domain. Summary: Members of the \' frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7 and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain testis eye skeletal muscle and kidney. [1] Winn R. A. Marek L. Han S. Y. Rodriguez K. Rodriguez N. Hammond M. Van Scoyk M. Acosta H. Mirus J. Barry N. et al. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation[2] Wang Y. K. Sporle R. Paperna T. Schughart K. and Francke U. et al. Characterization and expression pattern of the frizzled gene Fzd9 the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome[3] Finch P. W. He X. Kelley M. J. Uren A. Schaudies R. P. Popescu N. C. Rudikoff S. Aaronson S. A. Varmus H. E. and et al. Purification and molecular cloning of a secreted Frizzled-related antagonist of Wnt action[4] Wang Y. K. Samos C. H. Peoples R. Perez-Jurado L. A. Nusse R. and Francke U. A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11. 23[5] Datta D. V. et al. Viral hepatitis (Chandigarh study)[6] Wang Y. -K. Samos H. C. Peoples R. Perez-Jurado L. A. Nusse R. Francke U. A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11. 23. [7] Hillier L. W. Fulton R. S. Fulton L. A. Graves T. A. Pepin K. H. Wagner-McPherson C. Layman D. Maas J. Jaeger S. Walker R. et al. The DNA sequence of human chromosome 7. [8] Tanaka S. Akiyoshi T. Mori M. Wands J. R. Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.