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Rabbit anti TANK (CT)

Rabbit anti TANK (CT)

Manufacturer	GENWAY
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody
Specific against	other
Applications	WB
Amount	0,1 mg
Host	Rabbit
Item no.	18-511-244443
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-4512E7
Host Animal:	Rabbit
Immunogen:	Synthetic peptide corresponding to 14 amino acids near the carboxy terminal of human TANK (Genbank accession No. NP_004171)
Specificity:	TRAF family member-associated NF-kappaB activator (TANK) C-terminal
Specificity:	Reacts with the C-terminus of human mouse and rat TANK. TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction (1 2). Specifically ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. At least 2 isoforms of TANK are known to exist.
Type of Product:	Polyclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	Lot specificPreservatives: NaN3
Buffer:	PBSApplications Notes : Suitable for use in Western blot (1?2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti TANK (CT). Rabbit Antibody to TRAF family member-associated NF-kappaB activator (TANK) C-terminal
Function:	Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40 TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
Subunit:	Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK IKBKB and IKBKG.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Ubiquitous.
Ptm:	Phosphorylated by IKBKE.
Similarity:	Contains 1 C2H2-type zinc finger.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,1 mg

available

Delivery expected until 6/13/2024