RABBIT ANTI CASPASE-7 (N-TERMINAL)

CASPASE-7 (N-TERMINAL)

Phosphate buffered saline

A 16 amino acid peptide from human Caspase-7 amino-terminus

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a \' 216-Asp-|-Gly-217\' bond. Overexpression promotes programmed cell death. Catalytic activityStrict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. Enzyme regulationInhibited by isatin sulfonamides. Subunit structureHeterotetramer that consists of two anti-parallel arranged heterodimers each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Ref. 13Subcellular locationCytoplasm. Tissue specificityHighly expressed in lung skeletal muscle liver kidney spleen and heart and moderately in testis. No expression in the brain. Post-translational modificationCleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3 and vice versa also occur. Ref. 10Sequence similaritiesBelongs to the peptidase C14A family. 1. Cao Z. et al. (2001) Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5 6-Dimethylxanthenone-4-acetic acid (DMXAA). Cancer Res. 61: 1517 - 1521. [1] \" Isolation and bacterial expression of a murine alpha leukocyte interferon gene. \" Daugherty B. Martin-Zanca D. Kelder B. Collier K. Seamans T. C. Hotta K. Pestka S. J. Interferon Res. 4:635-643(1984) [PubMed: 6094686] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. [2] \" A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. \" Mural R. J. Adams M. D. Myers E. W. Smith H. O. Miklos G. L. Wides R. Halpern A. Li P. W. Sutton G. G. Nadeau J. Salzberg S. L. Holt R. A. Kodira C. D. Lu F. Chen L. Deng Z. Evangelista C. C. Gan W. Heiman T. J. Li J. Li Z. Merkulov G. V. Milshina N. V. Naik A. K. Qi R. Shue B. C. Wang A. Wang J. Wang X. Yan X. Ye J. Yooseph S. Zhao Q. Zheng L. Zhu S. C. Biddick K. Bolanos R. Delcher A. L. Dew I. M. Fasulo D. Flanigan M. J. Huson D. H. Kravitz S. A. Miller J. R. Mobarry C. M. Reinert K. Remington K. A. Zhang Q. Zheng X. H. Nusskern D. R. Lai Z. Lei Y. Zhong W. Yao A. Guan P. Ji R. R. Gu Z. Wang Z. Y. Zhong F. Xiao C. Chiang C. C. Yandell M. Wortman J. R. Amanatides P. G. Hladun S. L. Pratts E. C. Johnson J. E. Dodson K. L. Woodford K. J. Evans C. A. Gropman B. Rusch D. B. Venter E. Wang M. Smith T. J. Houck J. T. Tompkins D. E. Haynes C. Jacob D. Chin S. H. Allen D. R. Dahlke C. E. Sanders R. Li K. Liu X. Levitsky A. A. Majoros W. H. Chen Q. Xia A. C. Lopez J. R. Donnelly M. T. Newman M. H. Glodek A. Kraft C. L. Nodell M. Ali F. An H. J. Baldwin-Pitts D. Beeson K. Y. Cai S. Carnes M. Carver A. Caulk P. M. Center A. Chen Y. H. Cheng M. L. Coyne M. D. Crowder M. Danaher S. Davenport L. B. Desilets R. Dietz S. M. Doup L. Dullaghan P. Ferriera S. Fosler C. R. Gire H. C. Gluecksmann A. Gocayne J. D. Gray J. Hart B. Haynes J. Hoover J. Howland T. Ibegwam C. Jalali M. Johns D. Kline L. Ma D. S. MacCawley S. Magoon A. Mann F. May D. McIntosh T. C. Mehta S. Moy L. Moy M. C. Murphy B. J. Murphy S. D. Nelson K. A. Nuri Z. Parker K. A. Prudhomme A. C. Puri V. N. Qureshi H. Raley J. C. Reardon M. S. Regier M. A. Rogers Y. H. Romblad D. L. Schutz J. Scott J. L. Scott R. Sitter C. D. Smallwood M. Sprague A. C. Stewart E. Strong R. V. Suh E. Sylvester K. Thomas R. Tint N. N. Tsonis C. Wang G. Wang G. Williams M. S. Williams S. M. Windsor S. M. Wolfe K. Wu M. M. Zaveri J. Chaturvedi K. Gabrielian A. E. Ke Z. Sun J. Subramanian G. Venter J. C. Pfannkoch C. M. Barnstead M. Stephenson L. D. Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL30976. 1. [3] Mural R. J. Adams M. D. Myers E. W. Smith H. O. Venter J. C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL30976. 1. [4] Tracey A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI16217. 1.