CTRP5


Manufacturer	GENWAY
Category	Metabolism Glucose Homeostasis Antibodies Obesity Western Blot Primary Antibodies
Type	Antibody
Specific against	other
Applications	WB
Amount	0.1 mg
Item no.	18-783-75559
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-1CD3DF
Specificity:	CTRP5NCBI
Gene ID:	114902
Specificity:	CTRP5
Immunogen:	A 15 amino acid peptide from near the centre of human CTRP5.
Specificity Note:	This product detects an epitope within C1q and TNF related protein 5 (CTRP5) also known as C1QTNF5. CTRP5 encodes a novel short chain collagen which is widely expressed with highest expression in the retinal pigment epithelium (RPE) and ciliary epithelium (CE). It is a secretory protein which associates with membrane type frizzled related protein (MFRP) and may aid the adhesion of basal RPE to Bruch membrane. Mutation to CTRP5 causes it to be retained in the endoplasmic reticulum and can lead to late-onset retinal degeneration (LORD) and long anterior lens zonules. CTRPs are often highly modified post-translationally so whereas the predicted molecular weight for CTRP5 is 25kD This product detects a single band at 40kD.
Antiserum Preparation:	Antisera to human CTRP5 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02%Sodium AzideSuggested
Dilution:	Western Blot: This product detects a band of approximately 39kDa in caco-2 cell lysate. Suggested
Dilution:	Western Blotting - 1 - 5ug/ml
Subcellular Location:	Secreted (Probable).
Disease:	Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD) [MIM:605670]. LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus progressing to severe central and peripheral degeneration with choroidal neovascularization and chorioretinal atrophy.
Similarity:	Contains 1 C1q domain.
Similarity:	Contains 1 collagen-like domain. 1. Shu. X. et al. (2006) Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5. 2. Ayyagari. R. et al. (2005) Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation.

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Amount: 0.1 mg

available

Delivery expected until 6/13/2024