CD253


Item no.	18-783-75597
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Breast Cancer
Type	Antibody
Applications	WB, IHC, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B1271C
Similar products	18-783-75597
Available
Genway ID:	GWB-B1271C
Specificity:	CD253NCBI
Gene ID:	8743
Specificity:	CD253
Immunogen:	Recombinant human CD253
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6. 0 is recommended for this purpose. Histology: Metastatic carcinoma of lymph node from breast tissue
Antiserum Preparation:	Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		None present Reconstitution: Reconstitute with 0. 1ml distilled water. For long term storage the addition of 0. 09% sodium azide is recommended. Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 0. 25ug/mlmmunohistology - Resin - 0. 5ug/mlWestern Blotting - 0. 1 - 0. 2ug/ml
Function:	Cytokine that binds to TNFRSF10A/TRAILR1 TNFRSF10B/TRAILR2 TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Cofactor: Binds 1 zinc ion per trimer.
Subunit:	Homotrimer.
Subcellular Location:	Membrane; Single-pass type II membrane protein (Potential).
Tissue Specificity:	Widespread; most predominant in spleen lung and prostate.
Similarity:	Belongs to the tumor necrosis factor family. 1. Almasan. A. and Ashkenazi. A. (2003) Apo2L/TRAIL: apoptosis signaling. biology and potential for cancer therapy.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/27/2025

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