4EBP1

GWB-E14B3C

1978

Synthetic peptide corresponding to a region within human 4EBP1.

Antisera to human 4EBP1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Western Blotting - 1:1000 - 1:6000 Summary: This protein is one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5\' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation. Summary: This protein is one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5\' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].