PP2B (N-term)

GWB-A43BA1

A synthetic peptide corresponding to residues on the N-terminus of human PP2B was used as an immunogen.

WB: 1:1 000 - 10 000FC: 1:100IP: 1:100. The calcium- and calmodulin-dependent protein phosphatase calcineurin (PP2B) has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fiber gene expression in skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus thereby potentially coupling muscle activity to calcineurin activation (1). The Z-disc is a highly specialized multiprotein complex of striated muscles that serves as the interface of the sarcomere and the cytoskeleton. Calsarcins represent a novel family of sarcomeric proteins that serve as focal points for the interactions of an array of proteins involved in Z-disc structure and signal transduction in striated muscle (2). 1. Frey N et al. Proc Natl Acad Sci 97(26):14632-7 20002. Frey N et al. J Biol Chem 277(16):13998-4004 20023. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487