Fibrinogen alpha chain

GWB-B1ABBA

A synthetic peptide corresponding to residues in human Fibrinogen (alpha chain) was used as an immunogen.

WB: 1:2 000 - 10 000IHC: 1:50 - 100ICC: 1:50 - 100IP: 1:50. Fibrinogen is a plasma glycoprotein synthesized primarily in the liver (1). It is comprised of two identical molecular halves each consisting of three non-identical subunit polypeptides designated as A alpha B beta- and gamma-chains held together by multiple disulfide bonds (2). Fibrinogen acts as the main factor in the formation of a blood clot by polymerization to a fibrin network and by enabling platelets to aggregate (3). The conversion of fibrinogen to fibrin is triggered by thrombin which cleaves fibrinopeptides A and B from alpha and beta chains and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Defects in fibrinogen are a cause of congenital afibrinogenemia a rare autosomal recessive disorder and amyloidosis type 8 also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis (4). 1. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487