COX1 [AS70]

GWB-7E109F

IgG1

COX1

0. 08% Sodium Azide; Constituents: PBS

Cytoplasmic Cyclooxygenase (COX) also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2 PGE2 PGF2a PGI2 and Thromboxane A2. Thus COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX COX-1 and COX-2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins which inhibit gastric secretion. It can be induced in monocytes macrophages and other cells. It is induced as part of the inflammatory response by IL-1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2.

Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O. Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).

Homodimer.

This enzyme acts both as a dioxygenase and as a peroxidase.

Belongs to the prostaglandin G/H synthase family.