Leptin [4F8]

4F8

Recombinant full length protein.

Leptin

Phosphate-buffered saline pH 7. 4 containing 0. 1% sodium azide

Secreted Myeloma: Sp2/0 Leptin (from the Greek leptos meaning thin) is a protein hormone with important effects in regulating body weight metabolism and reproductive function. The protein is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight as well as in T lymphocytes and vascular endothelial cells. Leptin\' s effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger body temperature and energy expenditure.

Interacts with SIGLEC6.

Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].