Progesterone receptor [PR-AT 4.14]

GWB-238EBF

IgG1

Human

Progesterone receptor

1 mg/ml Storage

For IHC-Fr: Use at concentration of 5 ug/ml. For IHC-P: Use at a concentration of 5 ug/ml. For IP: Use at an assay dependent dilution. For WB: Use at a concentration of 5 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences resulting in activated transcription. When bound to DNA PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e. g. SRC 1) or corepressor (e. g. NCoR) proteins.

Interacts with CUEDC2 SMARD1 and with UNC45A.

Composed of three domains: a modulating N-terminal domain a DNA-binding domain and a C-terminal steroid-binding domain.

Contains 1 nuclear receptor DNA-binding domain.