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PAPP-A (proMBP)

PAPP-A (proMBP)

Item no.	20-511-240912
Manufacturer	GENWAY
Amount	1 mg
Category	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Bone Cancer
Type	Antibody
Applications	WB, ELISA
Clone	110000
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3D9E15
Similar products	20-511-240912
Available
Genway ID:	GWB-3D9E15
Isotype:	IgG
Clone:	110000Host Animal: Mouse. Hybridization of SP2/0 myeloma
Type of Product:	Monoclonal Antibodies to Hormones and Steroids
Concentration:	3. 4mg/ml Preservatives: NaN3
Buffer:	PBS pH 7. 4Applications Notes : Detection of human PAPP-A antigen in immunoassay. Recognizes proMBP subunit in Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PAPP-A (proMBP). Monoclonal Antibody to Human Pregnancy Associated Plasma Protein A (PAPP-A)
Function:	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5 resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Catalytic Activity:	Cleavage of the 135-Met-\|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4 and the 143-Ser-\|-Lys-144 bond in IGFBP-5. Cofactor: Binds 1 zinc ion per subunit (By similarity).
Enzyme Regulation:	Inhibited by complexation with the proform of PRG2.
Subunit:	Homodimer; disulfide-linked. In pregnancy serum predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.
Subcellular Location:	Secreted.
Tissue Specificity:	High levels in placenta and pregnancy serum. In placenta expressed in X cells in septa and anchoring villi and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney myometrium endometrium ovaries breast prostate bone marrow colon fibroblasts and osteoblasts. Developmental Stage: Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
Induction:	By 8-bromoadenosine-3\' 5\' -phosphate.
Ptm:	There appear to be no free sulfhydryl groups.
Similarity:	Belongs to the peptidase M43B family [view classification].
Similarity:	Contains 5 Sushi (CCP/SCR) domains.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 8/28/2025

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