Leptin

Item no.	20-511-242294
Manufacturer	GENWAY
Amount	0.1 ml
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Obesity Immunohistochemistry Western Blot Endocrine Regulation of Lipid Metabolism Primary Antibodies
Type	Antibody
Applications	WB, IHC
Clone	BDI170
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D82383
Similar products	20-511-242294
Available
Genway ID:	GWB-D82383
Isotype:	IgG2a
Clone:	BDI170Host Animal: Mouse
Immunogen:	Synthetic human leptin (131-145) attached to a carrier protein
Specificity:	Human Leptin. Binds to the carboxyl terminal region of the protein and to the intact leptin specifically in ELISA. Western blot and immunocytochemistry.
Type of Product:	Monoclonal Antibodies to Proteins and Bioactive Peptides
Concentration:	Not determined
Buffer:	Not applicableApplications Notes : Has been found to stain specifically human adipocytes at a 1:1000 dilution. The ability to bind to leptin in adipocytes was examined in cells fixed with neutral buffered formalin. The fixed cells were incubated for 20 minutes with 4% normal goat serum reacted for 60 minutes with the diluted monoclonal antibody and then with FITC-conjugated Goat anti-Mouse IgG. The immunofluorescent staining pattern was observed using epifluorescence microscopy. Western immunoblots of adipocyte homogenates resulted in a single band being detected at ~16 kDa at a dilution of 1:4000. Suitable for use in IHC using frozen sections. Paraffin-embedded sections have not been tested. MAb to Leptin. Monoclonal Antibody to Human Leptin (residues 131-145)
Function:	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subunit:	Interacts with SIGLEC6.
Subcellular Location:	Secreted.
Disease:	Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
Similarity:	Belongs to the leptin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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