CD11a

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone I21/7
Applications FC, IP
Amount 0.025 mg
ArtNr 20-783-310065
Available
Genway ID:
GWB-8C81CB
Specificity:
CD11aNCBI
Gene ID:
16408
Specificity:
CD11a
Clone:
I21/7
Immunogen:
Whole BW5147 cells.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction cytotoxic T-cell mediated killing and antibody dependent killing by granulocytes and monocytes.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Leukocytes.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain. 1. Trowbridge. I. S. and Omary. M. B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen MAC-1. 2. Champe. M. et al. (1995) Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen-1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a. 3. Springer. T. et al. (1982) LFA-1 and Lyt-2. 3. molecules associated with T lymphocyte-mediated killing; and Mac-1. an LFA-1 homologue associated with complement receptor function 4. Falanga. P. B. and Butcher E. C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. 5. Campbell. S. B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells 6. Talento. A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival. 7. Barret. T. B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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