CD91


Manufacturer	GENWAY
Category	Oncology Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Obesity Flow Cytometry Lipoprotein Receptors & Associated Proteins Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody
Specific against	other
Clone	A2Mr alpha-2
Applications	FC
Amount	25 TESTS
Item no.	20-783-310214
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-A52515
Specificity:	CD91NCBI
Gene ID:	4035
Specificity:	CD91
Clone:	A2Mr alpha-2
Immunogen:	Purified alpha2 macroglobulin receptor
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the NS1 mouse myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin) as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events such as APP metabolism kinase-dependent intracellular signaling neuronal calcium signaling as well as neurotransmission.
Subunit:	Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1 LRP1 and CUBNI. Interacts with SNX17 PID1/PCLI1 PDGF and CUBN. The intracellular domain interacts with SHC1 GULP1 and DAB1. Interacts with LRPAP1.
Subcellular Location:	Low-density lipoprotein receptor-related protein 1 85 kDa
Subunit:	Cell membrane; Single-pass type I membrane protein. Membrane coated pit.
Subcellular Location:	Low-density lipoprotein receptor-related protein 1 515 kDa
Subunit:	Cell membrane; Peripheral membrane protein; Extracellular side. Membrane coated pit.
Subcellular Location:	Low-density lipoprotein receptor-related protein 1 intracellular
Domain:	Cytoplasm. Nucleus. Note=After cleavage the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Specificity:	Most abundant in liver brain and lung.
Ptm:	Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
Ptm:	The N-terminus is blocked.
Ptm:	Phosphorylated on serine and threonine residues.
Ptm:	Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Similarity:	Belongs to the LDLR family.
Similarity:	Contains 22 EGF-like domains.
Similarity:	Contains 31 LDL-receptor class A domains.
Similarity:	Contains 34 LDL-receptor class B repeats. 1. Moestrup. S. K. et al. (1992) Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. 2. Moestrup. S. K. and Hokland. P. (1992) Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells.

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Amount: 25 TESTS

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Delivery expected until 5/30/2024