CD49b

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 31H4
Applications FC, IP, ELISA
Amount 0.025 mg
ArtNr 20-783-310224
Available
Genway ID:
GWB-9866B5
Specificity:
CD49bNCBI
Gene ID:
3673
Specificity:
CD49b
Clone:
31H4
Immunogen:
Purified human b1 integrin preparation from HT1080 fibrosarcoma cell extract.
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the X63/Ag8. 653 mouse myeloma cell line.
Specificity Note:
31H4 has been identified as being capable of immunoprecipitating the integrin a2 subunit from human cell-lines surface labelled with 125I. It has been confirmed specific to a2 by relative expression of antigen on various cell lines by flow cytometry and recognition of affinity purified a2b1 in dot blots.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Dilution:
Suggested
Dilution:
Flow Cytometry - 1/25 - 1/50Immunohistology - Resin - 10ug/mlImmunoprecipitation - 25ug/ml - 50ug/ml
Function:
Integrin alpha-2/beta-1 is a receptor for laminin collagen collagen C-propeptides fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Polymorphism:
Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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