CD146

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone OJ79c
Applications FC
Amount 0.025 mg
ArtNr 20-783-310251
Available
Genway ID:
GWB-883F89
Specificity:
CD146NCBI
Gene ID:
4162
Specificity:
CD146
Clone:
OJ79c
Immunogen:
Recombinant human MUC18 (D1-D5) Fc protein.
Fusion Partner:
Spleen cells from immunised mice were fused with cells of the mouse Sp2/0 Ag. 14 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Plays a role in cell adhesion and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2 and a transient increase in the intracellular calcium concentration.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 2 Ig-like V-type (immunoglobulin-like) domains. 1. Kuzu. I. et al. (1993) Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumours.
Amount: 0.025 mg
Available: In stock
Listprice: €218.13
Discount: -10.0%
Price: €196.32
You save: €21.81
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