CD79b

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone AT107-2
Applications WB, FC, IP, ELISA
Amount 0.025 mg
ArtNr 20-783-310279
Available
Genway ID:
GWB-674A15
Specificity:
CD79bNCBI
Gene ID:
974
Specificity:
CD79b
Clone:
AT107-2
Immunogen:
Peptide containing 20 amino acid residues from the cytoplasmic domain of human CD79b conjugated to Keyhole Limpet Hemocyanin (KLH).
Fusion Partner:
Spleen cells from immunised rat were fused with cells of the mouse NS-1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
TRIS buffered saline pH8. 0
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. We recommend the use of Leucoperm for this purpose. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100
Function:
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Subunit:
Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity).
Tissue Specificity:
B-cells.
Ptm:
Phosphorylated on tyrosine upon B-cell activation.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Similarity:
Contains 1 ITAM domain.
Amount: 0.025 mg
Available: In stock
Listprice: €156.78
Discount: -10.0%
Price: €141.10
You save: €15.68
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