Antibodies

CD49e

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone HM alpha 5
Applications FC
Amount 0.025 mg
ArtNr 20-783-310359
Available
Genway ID:
GWB-83F7E1
Specificity:
CD49eNCBI
Gene ID:
16402
Specificity:
CD49e
Clone:
HM alpha 5
Immunogen:
Purified mouse VLA-5 protein.
Fusion Partner:
Spleen cells from immunised Armenian Hamsters were fused with cells of the mouse P3U1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Yasuda. M. et al. (1995) Expression and function of fibronectin binding integrins on rat mast cells. 2. Miyake. S. et al. (1994) Identification of collagen and laminin receptor integrins on murine T lymphocytes.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Price: €182.24
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