CD62P

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone Psel. KO. 2.
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310472
Available
Genway ID:
GWB-12B709
Specificity:
CD62PNCBI
Gene ID:
6403
Specificity:
CD62P
Clone:
Psel. KO. 2. 12
Immunogen:
CD62P transfected 300. 19 cells.
Fusion Partner:
Spleen cells from immunised CD62P knock-out mice (Strain C57/B6) were fused with cells of the NS-1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100
Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Subunit:
Interacts with SNX17. Interacts with PSGL1/SEPL and mediateS neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope and specific tyrosine sulfation on PSGL1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists P-selectin is transported rapidly to the cell surface.
Disease:
Defects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor sensory and/or cognitive function. Ischemic strokes resulting from vascular occlusion is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Similarity:
Belongs to the selectin/LECAM family.
Similarity:
Contains 1 C-type lectin domain.
Similarity:
Contains 1 EGF-like domain.
Similarity:
Contains 9 Sushi (CCP/SCR) domains. 1. Massaguer. A. et al. (2000) Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P). 2. Massaguer. A. et al. (2003) Characterization of platelet and soluble-porcine P-selectin (CD62P). 3. 3. Massaguer. A. et al. (2002) Reactivity of CD62P workshop mAbs with resting and activated platelets from different animal species. In: Leucocyte Typing VII. Edited by Mason. D. et al. Oxford University Press. pp 342-343.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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