CD62P


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	Psel. KO. 2.
Applications	FC, IP, IHC
Amount	0.025 mg
Item no.	20-783-310472
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-12B709
Specificity:	CD62PNCBI
Gene ID:	6403
Specificity:	CD62P
Clone:	Psel. KO. 2. 12
Immunogen:	CD62P transfected 300. 19 cells.
Fusion Partner:	Spleen cells from immunised CD62P knock-out mice (Strain C57/B6) were fused with cells of the NS-1 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/50 - 1/100
Function:	Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Subunit:	Interacts with SNX17. Interacts with PSGL1/SEPL and mediateS neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope and specific tyrosine sulfation on PSGL1.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists P-selectin is transported rapidly to the cell surface.
Disease:	Defects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor sensory and/or cognitive function. Ischemic strokes resulting from vascular occlusion is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Similarity:	Belongs to the selectin/LECAM family.
Similarity:	Contains 1 C-type lectin domain.
Similarity:	Contains 1 EGF-like domain.
Similarity:	Contains 9 Sushi (CCP/SCR) domains. 1. Massaguer. A. et al. (2000) Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P). 2. Massaguer. A. et al. (2003) Characterization of platelet and soluble-porcine P-selectin (CD62P). 3. 3. Massaguer. A. et al. (2002) Reactivity of CD62P workshop mAbs with resting and activated platelets from different animal species. In: Leucocyte Typing VII. Edited by Mason. D. et al. Oxford University Press. pp 342-343.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.025 mg

available

Delivery expected until 5/30/2024