CD51


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	RMV-7
Applications	FC, IP, IHC
Amount	0.025 mg
Item no.	20-783-310489
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-24C6A8
Specificity:	CD51
Specificity:	CD51
Clone:	RMV-7
Immunogen:	Cultured LAK cells from Balb/c mice.
Fusion Partner:	Spleen cells from immunised SD rats were fused with the cells of the P3X. 63Ag8. 653 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) Suggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/25 - 1/100Immunohistology - Frozen - 1/25 - 1/100
Function:	The alpha-V integrins are receptors for vitronectin cytotactin fibronectin fibrinogen laminin matrix metalloproteinase-2 osteopontin osteomodulin prothrombin thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1 beta-3 beta-5 beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats. 1. Takahashi K. et al. (1990) A murine very late activation antigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-target cell interaction.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.025 mg

available

Delivery expected until 5/30/2024