CD51

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone RMV-7
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310489
Available
Genway ID:
GWB-24C6A8
Specificity:
CD51
Specificity:
CD51
Clone:
RMV-7
Immunogen:
Cultured LAK cells from Balb/c mice.
Fusion Partner:
Spleen cells from immunised SD rats were fused with the cells of the P3X. 63Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/25 - 1/100Immunohistology - Frozen - 1/25 - 1/100
Function:
The alpha-V integrins are receptors for vitronectin cytotactin fibronectin fibrinogen laminin matrix metalloproteinase-2 osteopontin osteomodulin prothrombin thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1 beta-3 beta-5 beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Takahashi K. et al. (1990) A murine very late activation antigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-target cell interaction.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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