CD3

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone KT3
Applications FC, IHC
Amount 0.025 mg
ArtNr 20-783-310686
Available
Genway ID:
GWB-1B8405
Specificity:
CD3NCBI
Gene ID:
12501
Specificity:
CD3
Clone:
KT3
Fusion Partner:
Spleen cells from immunised SD rats were fused with cells of the NSO mouse myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/100
Function:
The CD3 complex mediates signal transduction.
Subunit:
The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma delta epsilon zeta and eta.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Disease:
Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Similarity:
Contains 1 ITAM domain. 1. Tomonari. K. (1988) A rat antibody against a structure functionally related to the mouse T- cell receptor/T3 complex. 2. Tomonari. K. (1988) T-cell receptor-specific monoclonal antibodies against a V beta 11-positive mouse T-cell clone. 3. Lacroix-Lamandà © . S. et al. (2002) Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal cell line after cryptosporidium parvum infection.
Amount: 0.025 mg
Available: In stock
Listprice: €168.20
Discount: -10.0%
Price: €151.38
You save: €16.82
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