Antibodies

CD169

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone 3D6. 112
Applications FC
Amount 0.025 mg
ArtNr 20-783-310735
Available
Genway ID:
GWB-1D380F
Specificity:
CD169NCBI
Gene ID:
20612
Isotype:
IgG2a
Clone:
3D6. 112
Specificity:
This product recognises mouse CD169 a sialic acid binding site of sialoadhesin. CD169 is a macrophage receptor expressed on stromal macrophages in many tissues partialarly found in lymp nodes bone marrow and spleen
Immunogen:
Purified Sialoadhesin
Fusion Partner:
Spleen cells from an immunised AO rat were fused with the cells of the Y3 rat myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat - 1/5
Function:
Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes including granulocytes monocytes natural killer cells B-cells and CD8 T-cells. Preferentially binds to alpha-2 3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Secreted.
Tissue Specificity:
Expressed by macrophages in various tissues. High levels are found in spleen lymph node perivascular macrophages in brain and lower levels in bone marrow liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Similarity:
Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Crocker. P. R. et al. (1991) Purification and properties of sialoadhesin. a sialic acid-binding receptor of murine tissue macrophages.
Amount: 0.025 mg
Available: In stock
Listprice: €396.95
Price: €396.95
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