Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
3D6. 112 |
Applications |
FC |
Amount |
0.025 mg |
Item no. |
20-783-310735 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-1D380F |
Specificity: |
CD169NCBI |
Gene ID: |
20612 |
Isotype: |
IgG2a |
Clone: |
3D6. 112 |
Specificity: |
This product recognises mouse CD169 a sialic acid binding site of sialoadhesin. CD169 is a macrophage receptor expressed on stromal macrophages in many tissues partialarly found in lymp nodes bone marrow and spleen |
Immunogen: |
Purified Sialoadhesin |
Fusion Partner: |
Spleen cells from an immunised AO rat were fused with the cells of the Y3 rat myeloma cell line. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
Buffer Solution: |
Phosphate buffered saline |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested |
Dilution: |
Flow Cytometry - Neat - 1/5 |
Function: |
Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes including granulocytes monocytes natural killer cells B-cells and CD8 T-cells. Preferentially binds to alpha-2 3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. |
Subcellular Location: |
Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Subcellular Location: |
Isoform 2: Secreted. |
Tissue Specificity: |
Expressed by macrophages in various tissues. High levels are found in spleen lymph node perivascular macrophages in brain and lower levels in bone marrow liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. |
Similarity: |
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. |
Similarity: |
Contains 16 Ig-like C2-type (immunoglobulin-like) domains. |
Similarity: |
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Crocker. P. R. et al. (1991) Purification and properties of sialoadhesin. a sialic acid-binding receptor of murine tissue macrophages. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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