MOUSE ANTI hnRNPK

hnRNPK

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises hnRNP K (heterogeneous ribonucleotide protein K) a 464 amino acid acidic protein found in the nucleus cytoplasm and mitochondria shown to be involved in transcription mRNA shuttling and the translation and editing of RNA. Over-expression of hnRNP K has been demonstrated in cancerous tissue including that of the colon breast liver and lungs and its involvement in cell migration has been implicated in tumour metastasis. Studies have also shown that hnRNP K increases the transcriptional activity of the c-myc and c-src oncogenes. Recommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)

In case of ASFV infection there is a shift in the localization which becomes predominantly nuclear. Ref. 1Post-translational modificationArg-296 and Arg-299 are dimethylated probably to asymmetric dimethylarginine. Ref. 14Sequence similaritiesContains 3 KH domains. Mass spectrometryIsoform 1: Molecular mass is 50976. 25 Da from positions 1 - 463. Determined by MALDI. Ref. 10Sequence cautionThe sequence BAD92799. 1 differs from that shown. Reason: Erroneous initiation. [1] \" A second p53-related protein p73L with high homology to p73. \" Senoo M. Seki N. Ohira M. Sugano S. Watanabe M. Tachibana M. Tanaka T. Shinkai Y. Kato H. Biochem. Biophys. Res. Commun. 248:603-607(1998) [PubMed: 9703973] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [2] \" Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16. \" Augustin M. Bamberger C. Paul D. Schmale H. Mamm. Genome 9:899-902(1998) [PubMed: 9799841] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Keratinocyte and Skeletal muscle. [3] \" p63 a p53 homolog at 3q27-29 encodes multiple products with transactivating death-inducing and dominant-negative activities. \" Yang A. Kaghad M. Wang Y. Gillett E. Fleming M. D. Doetsch V. Andrews N. C. Caput D. McKeon F. Mol. Cell 2:305-316(1998) [PubMed: 9774969] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 6) NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-680 (ISOFORMS 1; 3 AND 5) FUNCTION TISSUE SPECIFICITY. [4] \" Cloning and functional analysis of human p51 which structurally and functionally resembles p53. \" Osada M. Ohba M. Kawahara C. Ishioka C. Kanamaru R. Katoh I. Ikawa Y. Nimura Y. Nakagawara A. Obinata M. Ikawa S. Nat. Med. 4:839-843(1998) [PubMed: 9662378] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5) VARIANT HEAD AND NECK CANCER LEU-184 VARIANT LUNG CARCINOMA PRO-187 VARIANT CERVICAL CANCER LEU-204. Tissue: Skeletal muscle. [5] \" Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. \" Hagiwara K. McMenamin M. G. Miura K. Harris C. C. Cancer Res. 59:4165-4169(1999) [PubMed: 10485447] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT COLON CANCER HIS-279 VARIANT OVARIAN CANCER ALA-560. [6] \" Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family. \" Lee L. A. Walsh P. Prater C. A. Su L. -J. Marchbank A. Egbert T. B. Dellavalle R. P. Targoff I. N. Kaufman K. M. Chorzelski T. P. Jablonska S. J. Invest. Dermatol. 113:146-151(1999) [PubMed: 10469295] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [7] \" Mutation and expression of the p51 gene in human lung cancer. \" Tani M. Shimizu K. Kawahara C. Kohno T. Ishimoto O. Ikawa S. Yokota J. Neoplasia 1:71-79(1999) [PubMed: 10935472] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 7) ALTERNATIVE SPLICING (ISOFORM 8). [8] \" Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L a novel dominant-negative isoform and loss of expression of the potential tumour suppressor p51. \" Senoo M. Tsuchiya I. Matsumura Y. Mori T. Saito Y. Kato H. Okamoto T. Habu S. Br. J. Cancer 84:1235-1241(2001) [PubMed: 11336476] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10) TISSUE SPECIFICITY (ISOFORM 10). [9] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph. [10] \" A new human p53 homologue. \" Trink B. Okami K. Wu L. Sriuranpong V. Jen J. Sidransky D. Nat. Med. 4:747-748(1998) [PubMed: 9662346] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-450 (ISOFORMS 2/4/8) SUBUNIT ZINC-BINDING DNA-BINDING. Tissue: Prostate.