HEAT SHOCK PROTEIN 27

HEAT SHOCK PROTEIN 27NCBI

HEAT SHOCK PROTEIN 27

Recombinant human HSP27

This product recognises human heat shock protein 27 which functions in signal transduction pathways. Expression of HSP27 is a poor prognostic factor in gastric carcinoma. Expression in some oestrogen receptor positive breast tumours may indicate a functional receptor pathway. Histology: Skin breast uterus cervix placenta.

Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It\' s recommended that the vial is gently mixed after reconstitution. Suggested

Immunohistology - Frozen - 1/20 - 1/40Immunohistology - Paraffin - 1/20 - 1/40Western Blotting - 1/100 - 1/250 Summary: The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq]. 1. Ciocca. D. R. et al. (1993) Biological and clinical implications of heat shock protein 27000 (Hsp27): a review.