C9


Item no.	20-783-74991
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies ELISA Primary Antibodies By Organ Skin Cancer
Type	Antibody
Applications	ELISA
Clone	002-94. 8. 8
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1F0814
Similar products	20-783-74991
Available
Genway ID:	GWB-1F0814
Specificity:	C9NCBI
Gene ID:	735
Specificity:	C9
Clone:	002-94. 8. 8
Immunogen:	Purified human C9
Specificity Note:	This product recognises complement component 9 (C9) a 71kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC) binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides. This product does not recognise MAC.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Borate buffered saline pH8. 2 - 8. 4
Preservative Stabilisers:		0. 02%Sodium Azide (NaN3)
Function:	C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers forming transmembrane channels.
Ptm:	Thrombin cleaves factor C9 to produce C9a and C9b.
Disease:	Defects in C9 are a cause of component C9 deficiency (C9D) [MIM:120940]. Patients with C9D suffer from recurrent bacterial infections predominantly from Neisseria meningitidis.
Similarity:	Belongs to the complement C6/C7/C8/C9 family.
Similarity:	Contains 1 EGF-like domain.
Similarity:	Contains 1 LDL-receptor class A domain.
Similarity:	Contains 1 MACPF domain.
Similarity:	Contains 1 TSP type-1 domain. 1. Huang. Y. et al. (2006) Defining the CD59-C9 binding interaction.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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