IgA

GWB-595C70

IgA

This product recognises the alpha heavy chain of rat immunoglobulin and does not cross react with other rat immunoglobulin classes.

Phosphate buffered saline pH7. 4

Suggested

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.

Contains 3 Ig-like (immunoglobulin-like) domains. 1. Kohler. G. & Milstein. C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity 2. Schulman. M. . Wilde. C. D. & Kohler. G. (1978) A better cell line for making hybridomas secreting specific antibodies 3. Bazin. H. . Beckers. A. & Querinjean. P. (1974) Three classes and four (sub)classes of rat immunoglobulins: IgM. IgA. IgE and IgG1. IgG2a. IgG2b. IgG2c 4. Bazin. H. . Beckers. A. . Urbain-Vansanten. G. . Pauwels. R. . Bruyns. C. . Tilkin. A. F. . Platteau. B. & Urbain. J. J. (1978) Transplantable IgD immunoglobulin-secreting tumors in rat 5. Bazin. H. . et al. (1984) Rat monoclonal antibodies. II. A rapid and efficient method of purification from ascitic fluid or serum 6. Grabar and Williams (1953) Method permitting the combined study of the electrophoretic and the immunochemical properties of protein mixtures; application to blood serum.