RECOMBINANT HUMAN ADIPONECTIN

GWB-2EEA16

Purified recombinant adiponectin expressed in High-5 insect cells.

Adiponectin is an adipokine exclusively secreted by adipocytes which plays a major role in the control of fat metabolism and insulin sensitivity through the regulation of energy homeostasis and glucose and lipid metabolism. A reduced level of plasma adiponectin is associated with type 2 diabetes and obesity insulin resistance. 1. Millard T. H. et al. (2005) Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. EMBO J. 24: 240-250. [1] \" Identification of BAIAP2 (BAI-associated protein 2) a novel human homologue of hamster IRSp53 whose SH3 domain interacts with the cytoplasmic domain of BAI1. \" Oda K. Shiratsuchi T. Nishimori H. Inazawa J. Yoshikawa H. Taketani Y. Nakamura Y. Tokino T. Cytogenet. Cell Genet. 84:75-82(1999) [PubMed: 10343108] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5) INTERACTION WITH BAI1 SUBCELLULAR LOCATION TISSUE SPECIFICITY. Tissue: Fetal brain. [2] \" Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. \" Okamura-Oho Y. Miyashita T. Ohmi K. Yamada M. Hum. Mol. Genet. 8:947-957(1999) [PubMed: 10332026] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4) PHOSPHORYLATION AT TYROSINE RESIDUES SUBCELLULAR LOCATION INTERACTION WITH ATN1 TISSUE SPECIFICITY. Tissue: Fetal brain. [3] \" Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. \" Miyahara A. Okumura-Oho Y. Miyashita T. Hoshika A. Yamada M. J. Hum. Genet. 48:410-414(2003) [PubMed: 12884081] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 4 AND 5). [4] Suzuki Y. Sugano S. Totoki Y. Toyoda A. Takeda T. Sakaki Y. Tanaka A. Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Brain. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6). Tissue: Brain and Duodenum. [6] \" A Fas-ligand associated factor 3 FLAF3 potentiates Fas-ligand stability. \" Hachiya T. Kobayasi A. Touji S. Tamai K. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-328. Tissue: Placenta. [7] \" IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. \" Miki H. Yamaguchi H. Suetsugu S. Takenawa T. Nature 408:732-735(2000) [PubMed: 11130076] [Abstract]Cited for: FUNCTION INTERACTION WITH RAC1; CDC42; WASF1 AND WASF2. [8] \" Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. \" Krugmann S. Jordens I. Gevaert K. Driessens M. Vandekerckhove J. Hall A. Curr. Biol. 11:1645-1655(2001) [PubMed: 11696321] [Abstract]Cited for: FUNCTION INTERACTION WITH CDC42 AND ENAH MUTAGENESIS OF PHE-427 AND PRO-428. [9] \" Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin. \" Govind S. Kozma R. Monfries C. Lim L. Ahmed S. J. Cell Biol. 152:579-594(2001) [PubMed: 11157984] [Abstract]Cited for: INTERACTION WITH CDC42 MUTAGENESIS OF ILE-267 TISSUE SPECIFICITY. [10] \" The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. \" Soltau M. Richter D. Kreienkamp H. -J. Mol. Cell. Neurosci. 21:575-583(2002) [PubMed: 12504591] [Abstract]Cited for: INTERACTION WITH SHANK1; SHANK2; SHANK3 AND CDC42 SUBCELLULAR LOCATION.