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LATS1 Antibody (N-term)

LATS1 Antibody (N-term)

Item no.	ABC-AP7035a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312\|EMBL:AAD168821}
Available
Primary Accession	O95835
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Bio References	Iida, S., et al., Oncogene 23(31):5266-5274 (2004). Yang, X., et al., Nat. Cell Biol. 6(7):609-617 (2004). Kamikubo, Y., et al., J. Biol. Chem. 278(20):17609-17614 (2003). Hisaoka, M., et al., Lab. Invest. 82(10):1427-1435 (2002). Hirota, T., et al., J. Cell Biol. 149(5):1073-1086 (2000).
Clonality	Polyclonal
Clone/Animal Names	RB3029
Gene ID	9113
Gene Name	LATS1 {ECO:0000312\|EMBL:AAD16882.1}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of anti-LATS1 Antibody (N-term) (Cat.#AP7035a) in K562 cell line lysates (35ug/lane). LATS1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	126870
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
NCBI Accession	NP_001257448.1; NP_004681.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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