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DNA PK (PRKDC) Antibody (C-term)

DNA PK (PRKDC) Antibody (C-term)

Item no.	ABC-AP7053b
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PRKDC, DNPK1, DNA-PKcs, HYRC, HYRC1, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, p460
Available
Primary Accession	P78527
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM]
Bio References	Goudelock, D.M., et al., J. Biol. Chem. 278(32):29940-29947 (2003). Ding, Q., et al., Mol. Cell. Biol. 23(16):5836-5848 (2003). Lucero, H., et al., J. Biol. Chem. 278(24):22136-22143 (2003). Calsou, P., et al., J. Mol. Biol. 326(1):93-103 (2003). Karpova, A.Y., et al., Proc. Natl. Acad. Sci. U.S.A. 99(5):2818-2823 (2002).
Clonality	Polyclonal
Clone/Animal Names	RB3465/3466
Gene ID	5591
Gene Name	PRKDC
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Anti-PRKDC Antibody (R4082) at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 469 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	469089
Antigen Region	4075-4104
Antigen Source	HUMAN
Target/Specificity	This DNA PK (PRKDC) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4075~4104 amino acids from the C-terminal region of human PRKDC.
NCBI Accession	NP_001075109.1; NP_008835.5

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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