p21 (CDKN1A) Antibody (C-term)

Primary Antibodies; Cancer; Cell Biology; Interleukin signaling

CDKN1A is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. Expression is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.

RB3180

Purified Rabbit Polyclonal Antibody (Pab)

18119

134-164

IF: 1:10~50
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50