TRAF2 Antibody (C-term)

Primary Antibodies; Cancer; Cardiovascular; Cell Biology; Signal Transduction; Ubiquitin E3 Ligases (RING Domain) Antibodies; RIG-l-like Receptor; Apoptosis; Apoptosis signaling; SARS-Human interaction partners

TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis.

RB13076

Purified Rabbit Polyclonal Antibody (Pab)

55859

343-372

WB: 1:1000
IHC-P: 1:10~50