COT (MAP3K8/MEKK8) Antibody (C-term)

Primary Antibodies; Cancer; Signal Transduction; Immunity; Toll receptor signaling; Toll-Like receptor signaling; T cell receptor signaling

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p15. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

RB0947; RB0948

Purified Rabbit Polyclonal Antibody (Pab)

52925

414-445

WB: 1:1000
IHC-P: 1:50~100
IHC-P: 1:50~100