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Paclitaxel (2mM in DMSO)

Paclitaxel (2mM in DMSO)

Item no.	TXD01
Manufacturer	Cytoskeleton
Amount	10 x 100 ul
Category	Cell Biology Cytoskeleton Reagents & Chemicals Biochemicals Mikrotubules
Type	Chemicals
Specific against	other
Citations	Kosturko, L. D., Maggipinto, M. J., D'Sa, C., Carson, J. H. and Barbarese, E. (2005). The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Mol. Biol. Cell 16, 1938-1947. Teckchandani, A. M., Birukova, A. A., Tar, K., Verin, A. D. and Tsygankov, A. Y. (2005). The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules. Exp. Cell Res. 306, 114-127. Nair, K. S., Hanson, S. M., Kennedy, M. J., Hurley, J. B., Gurevich, V. V. and Slepak, V. Z. (2004). Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors. J. Biol. Chem. 279, 41240-41248. Wagner, O. I., Ascano, J., Tokito, M., Leterrier, J. F., Janmey, P. A. and Holzbaur, E. L. (2004). The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol. Biol. Cell 15, 5092-5100 Ligon, L. A., Shelly, S. S., Tokito, M. and Holzbaur, E. L. (2003). The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. Mol. Biol. Cell 14, 1405-1417. Benink, H. A., Mandato, C. A. and Bement, W. M. (2000). Analysis of cortical flow models in vivo. Mol. Biol. Cell 11, 2553-2563. Korinek, W. S., Copeland, M. J., Chaudhuri, A. and Chant, J. (2000). Molecular linkage underlying microtubule orientation toward cortical sites in yeast. Science 287, 2257-2259.
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	tubulin, promote tubulin polymerization, promote microtubule stability, anti-mitotic drug, Paclitaxel, Taxol
Similar products	Paclitaxel, Taxol, tubulin, promote tubulin polymerization, promote microtubule stability, anti-mitotic drug
Shipping Condition	Room temperature
Available
Shipping Temperature	AT
Storage Conditions	On Arrival: 4°C
Delivery Time	1-2 Weeks
FAQs	Question 1: Can I mix taxol with my cell culture media and store at 4°C? Answer 1: No, we do not recommend storing cell culture media with taxol ((Cat. #TXD01). The taxol could precipitate out of solution at 4°C since the taxol is prepared in a 100% DMSO solution. Instead, add taxol to warm cell culture media to be used on the day of the experiment. Question 2: Can I incubate my cells with taxol to affect in vivo tubulin polymerization? Answer 2: In-house testing demonstrates that 1 hour with 0.5 or 1 mM taxol ((Cat. #TXD01) produces a robust increase in microtubules in Swiss 3T3 fibroblast cells.
Weight (grams)	26
Product Uses	Promote tubulin polymerization in vitro Promote microtubule stability in vitro Anti-mitotic drug in cell cultures
Material	Paclitaxel's (Taxol) usefulness as a laboratory tool is well established and lies in its ability to inhibit microtubule depolymerization. Thus, taxol stabilized microtubules are used as substrates for the identification and characterization of the ever increasing number of microtubule associated proteins. Paclitaxel is provided as a lyophilized powder.When resuspended in DMSO (not included) the paclitaxel is at 2 mM concentration. Purity In keeping with our policy of providing only the highest quality products, we are now pleased to inform you that Cytoskeleton is offering paclitaxel (taxol), from the Pacific yew tree, Taxus brevifolia at a chromatographic purity of >99.5%. This is the purest taxol commercially available for research use.
Biological Activity	We have determined that the microtubule stabilizing property of our product is equal or superior to any other commercially available taxols. Microtubules in 10 uM paclitaxel are stable at room temperature for over one week.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

TXD01.pdf

TXD01-datasheet.pdf

TXD01-safety-datasheet.pdf