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Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Tetramer Protein (MALS verified)

Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Tetramer Protein (MALS verified)

Item no.	HLP-H52H5-200ug
Manufacturer	ACROBiosystems
Amount	100 ug x 2
Quantity options	100 ug x 2 25 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Unconjugated, HIS
Purity	90%
Formula	PBS, pH7.4
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Category	Protein / Other Recombinant Proteins
Manufacturer - Conjugate / Tag	C-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	36.3 kDa and 11.7 kDa
Manufacturer - Format	Powder
Description	Human HLA-A02:01&B2M&p53 (HMTEVVRRC) Tetramer Protein (HLP-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & HMTEVVRRC).
Background	TP53 has been recognized as a tumor suppressor. 50% of cancers carry a TP53 mutation while many others affect other pathway components. High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells. The Human HLA-A0201 p53 (HMTEVVRRC) complex protein is a complex of HLA-A0201 of the MHC Class I, B2M, and HMTEVVRRC peptide of the p53.
Molecule	HLA-A*0201 & B2M & p53 (HMTEVVRRC)
Exp Region	Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide
Characteristics	Human HLA-A02:01&B2M&p53 (HMTEVVRRC) Tetramer Protein is assembled by biotinylated monomer (HLP-H82E4) and streptavidin.Biotinylated Human HLA-A02:01&B2M&p53 (HMTEVVRRC) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide. Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 40-43 kDa, 13 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

HLP-H52H5-200ug-datasheet.pdf

HLP-H52H5-200ug-safety-datasheet.pdf